Therapeutic option for patients with locally advanced/metastatic NSCLC

Zhou Qing
Poster presented at ESMO 2022 describing the effectiveness of combining a PD-1 inhibitor with a kinase inhibitor as compared to chemotherapy in patients with locally advanced/metastatic non-small cell lung cancer (NSCLC) previously treated with chemo and an anti-PD-[L]1 antibody.

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Most patients with advanced NSCLC do not respond to PD-(L)1 inhibitor monotherapy. Sitravatinib is an oral spectrum-selective tyrosine kinase inhibitor, which can reduce the number of myeloid-derived suppressor cells and regulatory T-cells and increase the ratio of M1/M2 polarized macrophages, promoting an antitumor microenvironment. TIS is an anti-PD-1 antibody engineered to minimize binding to FcγR on macrophages to abrogate antibody-dependent phagocytosis, a potential mechanism of resistance to PD-1 therapy. In a Phase 1
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