Factsheet: ASPEN - Zanubrutinib versus ibrutinib in patients with Waldenström's macroglobulinemia


Results from the ASPEN  trial (zanubrutinib vs ibrutinib) in Waldenström’s macroglobuliemia (WM) patients)

The phase 3 ASPEN study compared the efficacy and safety of ibrutinib with zanubrutinib in patients with Waldenström’s macroglobuliemia (WM). Patients with the MYD88=8W}x mutation were randomly assigned 1:1 to treatment with ibrutinib or zanubrutinib. The primary end point was the proportion of patients achieving a complete response (CR) or a very good partial response (VGPR) by independent review. In an additional cohort, the efficacy and safety of zanubrutinib in MYD88 wild type (MYD88=}) WM patients was evaluated.

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